Novel Tetra-Primer ARMS-PCR Assays for Thiopurine Intolerance Susceptibility Mutations NUDT15 c.415C>T and TPMT c.719A>G (TPMT*3C) in East Asians

Thiopurines are clinically useful in the management of diverse immunological and malignant conditions. Nevertheless, these purine analogues can cause lethal myelosuppression, which may be prevented by prospective testing for variants in the thiopurine S-methyltransferase (TPMT) and, in East Asians,...

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Detalles Bibliográficos
Autores principales: Ho, Chi-Chun, Fong, Wai-Ying, Lee, Yuen-Hon, Poon, Wing-Tat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664135/
https://www.ncbi.nlm.nih.gov/pubmed/29065511
http://dx.doi.org/10.3390/genes8100285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664135/
https://www.ncbi.nlm.nih.gov/pubmed/29065511
http://dx.doi.org/10.3390/genes8100285

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