Exploring the Multiligand Binding Specificity of Saposin B Reveals Two Binding Sites

[Image: see text] Saposin B (SapB) is a human lysosomal protein, critical for the degradation of O-sulfogalactosylceramide (sulfatide). SapB binds sulfatide and presents it to the active site of the enzyme arylsulfatase A. Deficiency of SapB leads to fatal activator-deficient metachromatic leukodyst...

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Detalles Bibliográficos
Autores principales: Tinklepaugh, Jay, Smith, Britannia M., Hanlon, Etta, Zubieta, Chloe, Bou-Abdallah, Fadi, Doyle, Robert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664142/
https://www.ncbi.nlm.nih.gov/pubmed/29104953
http://dx.doi.org/10.1021/acsomega.7b01334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664142/
https://www.ncbi.nlm.nih.gov/pubmed/29104953
http://dx.doi.org/10.1021/acsomega.7b01334

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