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Exploring the Multiligand Binding Specificity of Saposin B Reveals Two Binding Sites
[Image: see text] Saposin B (SapB) is a human lysosomal protein, critical for the degradation of O-sulfogalactosylceramide (sulfatide). SapB binds sulfatide and presents it to the active site of the enzyme arylsulfatase A. Deficiency of SapB leads to fatal activator-deficient metachromatic leukodyst...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664142/ https://www.ncbi.nlm.nih.gov/pubmed/29104953 http://dx.doi.org/10.1021/acsomega.7b01334 |