Remote stereoselective deconjugation of α,β-unsaturated esters by simple amidation reactions

The thermodynamically disfavored isomerization of α,β-unsaturated esters to deconjugated β,γ-unsaturated analogues occurs readily when coupled to an amidation. Within the framework of macrocyclic derivatives, it is shown that 15, 16, and 18 membered macrocycles react with tBuOK and anilines to gener...

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Detalles Bibliográficos
Autores principales: Vishe, Mahesh, Hrdina, Radim, Poblador-Bahamonde, Amalia I., Besnard, Céline, Guénée, Laure, Bürgi, Thomas, Lacour, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664367/
https://www.ncbi.nlm.nih.gov/pubmed/29142723
http://dx.doi.org/10.1039/c5sc01118c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664367/
https://www.ncbi.nlm.nih.gov/pubmed/29142723
http://dx.doi.org/10.1039/c5sc01118c

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