SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia

Although small molecule inhibitors of B-cell receptor-associated kinases have revolutionized therapy in chronic lymphocytic leukemia (CLL), responses are incomplete. Pro-survival signaling emanating from the microenvironment may foster therapeutic resistance of the malignant B cells resident in the...

Descripción completa

Detalles Bibliográficos
Autores principales: Paiva, Cody, Rowland, Taylor A., Sreekantham, Bhargava, Godbersen, Claire, Best, Scott R., Kaur, Prabhjot, Loriaux, Marc M., Spurgeon, Stephen E.F., Danilova, Olga V., Danilov, Alexey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664393/
https://www.ncbi.nlm.nih.gov/pubmed/28838991
http://dx.doi.org/10.3324/haematol.2017.170571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664393/
https://www.ncbi.nlm.nih.gov/pubmed/28838991
http://dx.doi.org/10.3324/haematol.2017.170571

Ejemplares similares