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Study of in vitro transcriptional binding effects and noise using constitutive promoters combined with UP element sequences in Escherichia coli

BACKGROUND: UP elements (upstream element) are DNA sequences upstream of a promoter that interact with the α-subunit of RNA polymerase (RNAP) and can affect transcription by altering the binding RNAP to DNA. However, details of UP element and binding affinity effects on transcriptional strength are...

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Detalles Bibliográficos
Autores principales: Yan, Qiang, Fong, Stephen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664571/
https://www.ncbi.nlm.nih.gov/pubmed/29118850
http://dx.doi.org/10.1186/s13036-017-0075-2