Software-aided approach to investigate peptide structure and metabolic susceptibility of amide bonds in peptide drugs based on high resolution mass spectrometry

Interest in using peptide molecules as therapeutic agents due to high selectivity and efficacy is increasing within the pharmaceutical industry. However, most peptide-derived drugs cannot be administered orally because of low bioavailability and instability in the gastrointestinal tract due to prote...

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Detalles Bibliográficos
Autores principales: Radchenko, Tatiana, Brink, Andreas, Siegrist, Yves, Kochansky, Christopher, Bateman, Alison, Fontaine, Fabien, Morettoni, Luca, Zamora, Ismael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665424/
https://www.ncbi.nlm.nih.gov/pubmed/29091918
http://dx.doi.org/10.1371/journal.pone.0186461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665424/
https://www.ncbi.nlm.nih.gov/pubmed/29091918
http://dx.doi.org/10.1371/journal.pone.0186461

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