LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells

Melanoma cells steer out of tumours using self-generated lysophosphatidic acid (LPA) gradients. The cells break down LPA, which is present at high levels around the tumours, creating a dynamic gradient that is low in the tumour and high outside. They then migrate up this gradient, creating a complex...

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Detalles Bibliográficos
Autores principales: Susanto, Olivia, Koh, Yvette W. H., Morrice, Nick, Tumanov, Sergey, Thomason, Peter A., Nielson, Matthew, Tweedy, Luke, Muinonen-Martin, Andrew J., Kamphorst, Jurre J., Mackay, Gillian M., Insall, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665449/
https://www.ncbi.nlm.nih.gov/pubmed/28871044
http://dx.doi.org/10.1242/jcs.207514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665449/
https://www.ncbi.nlm.nih.gov/pubmed/28871044
http://dx.doi.org/10.1242/jcs.207514

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