DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes

Mouse oocytes carrying DNA damage arrest in meiosis I, thereby preventing creation of embryos with deleterious mutations. The arrest is dependent on activation of the spindle assembly checkpoint, which results in anaphase-promoting complex (APC) inhibition. However, little is understood about how th...

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Detalles Bibliográficos
Autores principales: Lane, Simon I. R., Morgan, Stephanie L., Wu, Tianyu, Collins, Josie K., Merriman, Julie A., ElInati, Elias, Turner, James M., Jones, Keith T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665484/
https://www.ncbi.nlm.nih.gov/pubmed/28851706
http://dx.doi.org/10.1242/dev.153965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665484/
https://www.ncbi.nlm.nih.gov/pubmed/28851706
http://dx.doi.org/10.1242/dev.153965

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