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Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states
The N-terminal region of G protein-coupled receptors can be efficiently targeted for the generation of receptor-selective antibodies. These antibodies are useful for the biochemical characterization of the receptors. In this study, we developed a set of criteria to select the optimal epitope and app...
Autores principales: | Heimann, Andrea S., Gupta, Achla, Gomes, Ivone, Rayees, Rahman, Schlessinger, Avner, Ferro, Emer S., Unterwald, Ellen M., Devi, Lakshmi A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665533/ https://www.ncbi.nlm.nih.gov/pubmed/29091950 http://dx.doi.org/10.1371/journal.pone.0187306 |
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