Human microbiome signatures of differential colorectal cancer drug metabolism

It is well appreciated that microbial metabolism of drugs can influence treatment efficacy. Microbial β-glucuronidases in the gut can reactivate the excreted, inactive metabolite of irinotecan, a first-line chemotherapeutic for metastatic colorectal cancer. Reactivation causes adverse drug responses...

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Detalles Bibliográficos
Autores principales: Guthrie, Leah, Gupta, Sanchit, Daily, Johanna, Kelly, Libusha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665930/
https://www.ncbi.nlm.nih.gov/pubmed/29104759
http://dx.doi.org/10.1038/s41522-017-0034-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665930/
https://www.ncbi.nlm.nih.gov/pubmed/29104759
http://dx.doi.org/10.1038/s41522-017-0034-1

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