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Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation
Trisomy 21 (T21) causes Down syndrome (DS), but the mechanisms by which T21 produces the different disease spectrum observed in people with DS are unknown. We recently identified an activated interferon response associated with T21 in human cells of different origins, consistent with overexpression...
Autores principales: | Sullivan, Kelly D., Evans, Donald, Pandey, Ahwan, Hraha, Thomas H., Smith, Keith P., Markham, Neil, Rachubinski, Angela L., Wolter-Warmerdam, Kristine, Hickey, Francis, Espinosa, Joaquin M., Blumenthal, Thomas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665944/ https://www.ncbi.nlm.nih.gov/pubmed/29093484 http://dx.doi.org/10.1038/s41598-017-13858-3 |
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