Proteomic Analysis of Thiol Modifications and Assessment of Structural Changes in Hemoglobin Induced by the Aniline Metabolites N-Phenylhydroxylamine and Nitrosobenzene

MS-based proteomic analysis was combined with in silico quantum mechanical calculations to improve understanding of protein adduction by N-phenylhydroxylamine (PhNHOH) and nitrosobenzene (NOB), metabolic products of aniline. In vitro adduction of model peptides containing nucleophilic sidechains (Cy...

Descripción completa

Detalles Bibliográficos
Autores principales: Möller, Carolina, Davis, W. Clay, Thompson, Vanessa R., Marí, Frank, DeCaprio, Anthony P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665987/
https://www.ncbi.nlm.nih.gov/pubmed/29093547
http://dx.doi.org/10.1038/s41598-017-14653-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665987/
https://www.ncbi.nlm.nih.gov/pubmed/29093547
http://dx.doi.org/10.1038/s41598-017-14653-w

Ejemplares similares