HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19

Huntington’s disease (HD) is caused by aberrant expansion of polyglutamine (polyQ) in the N-terminus of huntingtin (Htt). Our previous study has demonstrated that HSP90 is involved in the triage decision of Htt, but how HSP90 recognizes and regulates Htt remains elusive. We investigated the interact...

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Detalles Bibliográficos
Autores principales: He, Wen-Tian, Xue, Wei, Gao, Yong-Guang, Hong, Jun-Ye, Yue, Hong-Wei, Jiang, Lei-Lei, Hu, Hong-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666004/
https://www.ncbi.nlm.nih.gov/pubmed/29093475
http://dx.doi.org/10.1038/s41598-017-13711-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666004/
https://www.ncbi.nlm.nih.gov/pubmed/29093475
http://dx.doi.org/10.1038/s41598-017-13711-7

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