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HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19
Huntington’s disease (HD) is caused by aberrant expansion of polyglutamine (polyQ) in the N-terminus of huntingtin (Htt). Our previous study has demonstrated that HSP90 is involved in the triage decision of Htt, but how HSP90 recognizes and regulates Htt remains elusive. We investigated the interact...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666004/ https://www.ncbi.nlm.nih.gov/pubmed/29093475 http://dx.doi.org/10.1038/s41598-017-13711-7 |