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Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3
In cancer cells the small compounds erastin and RSL3 promote a novel type of cell death called ferroptosis, which requires iron‐dependent accumulation of lipid reactive oxygen species. Here we assessed the contribution of lipid peroxidation activity of lipoxygenases (LOX) to ferroptosis in oncogenic...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666033/ https://www.ncbi.nlm.nih.gov/pubmed/28837253 http://dx.doi.org/10.1111/cas.13380 |