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Modelling pyruvate dehydrogenase under hypoxia and its role in cancer metabolism
Metabolism is the only biological system that can be fully modelled at genome scale. As a result, metabolic models have been increasingly used to study the molecular mechanisms of various diseases. Hypoxia, a low-oxygen tension, is a well-known characteristic of many cancer cells. Pyruvate dehydroge...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society Publishing
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666243/ https://www.ncbi.nlm.nih.gov/pubmed/29134060 http://dx.doi.org/10.1098/rsos.170360 |