Cellular Entry of the Diphtheria Toxin Does Not Require the Formation of the Open-Channel State by Its Translocation Domain

Cellular entry of diphtheria toxin is a multistage process involving receptor targeting, endocytosis, and translocation of the catalytic domain across the endosomal membrane into the cytosol. The latter is ensured by the translocation (T) domain of the toxin, capable of undergoing conformational ref...

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Detalles Bibliográficos
Autores principales: Ladokhin, Alexey S., Vargas-Uribe, Mauricio, Rodnin, Mykola V., Ghatak, Chiranjib, Sharma, Onkar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666346/
https://www.ncbi.nlm.nih.gov/pubmed/28937631
http://dx.doi.org/10.3390/toxins9100299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666346/
https://www.ncbi.nlm.nih.gov/pubmed/28937631
http://dx.doi.org/10.3390/toxins9100299

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