Jun dimerization protein 2 controls hypoxia‐induced replicative senescence via both the p16(Ink4a)‐pRb and Arf‐p53 pathways

The main regulators of replicative senescence in mice are p16(Ink4a) and Arf, inhibitors of cell cycle progression. Jun dimerization protein 2 (JDP2)‐deficient mouse embryonic fibroblasts are resistant to replicative senescence through recruitment of the Polycomb repressive complexes 1 and 2 to the...

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Detalles Bibliográficos
Autores principales: Nakade, Koji, Lin, Chang‐Shen, Chen, Xiao‐Yu, Tsai, Ming‐Ho, Wuputra, Kenly, Zhu, Zhi‐Wei, Pan, Jian‐Zhi, Yokoyama, Kazunari K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666393/
https://www.ncbi.nlm.nih.gov/pubmed/29123987
http://dx.doi.org/10.1002/2211-5463.12325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666393/
https://www.ncbi.nlm.nih.gov/pubmed/29123987
http://dx.doi.org/10.1002/2211-5463.12325

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