A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent against Starved Tumor Cells

Neopeltolide, an antiproliferative marine macrolide, is known to specifically inhibit complex III of the mitochondrial electron transport chain (mETC). However, details of the biological mode-of-action(s) remain largely unknown. This work demonstrates potent cytotoxic activity of synthetic neopeltol...

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Detalles Bibliográficos
Autores principales: Fuwa, Haruhiko, Sato, Mizuho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666428/
https://www.ncbi.nlm.nih.gov/pubmed/29053565
http://dx.doi.org/10.3390/md15100320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666428/
https://www.ncbi.nlm.nih.gov/pubmed/29053565
http://dx.doi.org/10.3390/md15100320

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