Mechanisms and energetics of free radical initiated disulfide bond cleavage in model peptides and insulin by mass spectrometry

We investigate the mechanism of disulfide bond cleavage in gaseous peptide and protein ions initiated by a covalently-attached regiospecific acetyl radical using mass spectrometry (MS). Highly selective S–S bond cleavages with some minor C–S bond cleavages are observed by a single step of collisiona...

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Detalles Bibliográficos
Autores principales: Sohn, Chang Ho, Gao, Jinshan, Thomas, Daniel A., Kim, Tae-Young, Goddard III, William A., Beauchamp, J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666513/
https://www.ncbi.nlm.nih.gov/pubmed/29142703
http://dx.doi.org/10.1039/c5sc01305d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666513/
https://www.ncbi.nlm.nih.gov/pubmed/29142703
http://dx.doi.org/10.1039/c5sc01305d

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