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Mechanisms and energetics of free radical initiated disulfide bond cleavage in model peptides and insulin by mass spectrometry
We investigate the mechanism of disulfide bond cleavage in gaseous peptide and protein ions initiated by a covalently-attached regiospecific acetyl radical using mass spectrometry (MS). Highly selective S–S bond cleavages with some minor C–S bond cleavages are observed by a single step of collisiona...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666513/ https://www.ncbi.nlm.nih.gov/pubmed/29142703 http://dx.doi.org/10.1039/c5sc01305d |