A new quinoxaline-containing peptide induces apoptosis in cancer cells by autophagy modulation

The synthesis of a new small library of quinoxaline-containing peptides is described. After cytotoxic evaluation in four human cancer cell lines, as well as detailed biological studies, it was found that the most active compound, RZ2, promotes the formation of acidic compartments, where it accumulat...

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Detalles Bibliográficos
Autores principales: Zamudio-Vázquez, Rubí, Ivanova, Saška, Moreno, Miguel, Hernandez-Alvarez, Maria Isabel, Giralt, Ernest, Bidon-Chanal, Axel, Zorzano, Antonio, Albericio, Fernando, Tulla-Puche, Judit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666514/
https://www.ncbi.nlm.nih.gov/pubmed/29142702
http://dx.doi.org/10.1039/c5sc00125k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666514/
https://www.ncbi.nlm.nih.gov/pubmed/29142702
http://dx.doi.org/10.1039/c5sc00125k

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