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A new quinoxaline-containing peptide induces apoptosis in cancer cells by autophagy modulation
The synthesis of a new small library of quinoxaline-containing peptides is described. After cytotoxic evaluation in four human cancer cell lines, as well as detailed biological studies, it was found that the most active compound, RZ2, promotes the formation of acidic compartments, where it accumulat...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666514/ https://www.ncbi.nlm.nih.gov/pubmed/29142702 http://dx.doi.org/10.1039/c5sc00125k |