Targeted Delivery of siRNA with pH-Responsive Hybrid Gold Nanostars for Cancer Treatment

In this work, we report the engineering of gold nanostars (GNS) to deliver small interfering RNA (siRNA) into HepG2 cells. The ligand DG-PEG-Lipoic acid (LA)-Lys-9R (hydrazone) was designed to functionalize GNS, and create the nanoparticles named as 9R/DG-GNS (hydrazone). In the ligand, 2-deoxygluco...

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Detalles Bibliográficos
Autores principales: Zhu, Hongyan, Liu, Wanwan, Cheng, Ziting, Yao, Ke, Yang, Yu, Xu, Bohui, Su, Gaoxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666711/
https://www.ncbi.nlm.nih.gov/pubmed/28937584
http://dx.doi.org/10.3390/ijms18102029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666711/
https://www.ncbi.nlm.nih.gov/pubmed/28937584
http://dx.doi.org/10.3390/ijms18102029

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