A Novel Fully Human Agonistic Single Chain Fragment Variable Antibody Targeting Death Receptor 5 with Potent Antitumor Activity In Vitro and In Vivo

Agonistic antibodies, which bind specifically to death receptor 5 (DR5), can trigger apoptosis in tumor cells through the extrinsic pathway. In this present study, we describe the use of a phage display to isolate a novel fully human agonistic single chain fragment variable (scFv) antibody, which ta...

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Detalles Bibliográficos
Autores principales: Lei, Gaoxin, Xu, Menglong, Xu, Zhipan, Gu, Lili, Lu, Chenchen, Bai, Zhengli, Wang, Yue, Zhang, Yongbo, Hu, Huajing, Jiang, Yiwei, Zhao, Wenfeng, Tan, Shuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666746/
https://www.ncbi.nlm.nih.gov/pubmed/28953230
http://dx.doi.org/10.3390/ijms18102064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666746/
https://www.ncbi.nlm.nih.gov/pubmed/28953230
http://dx.doi.org/10.3390/ijms18102064

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