CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation

Aging is considered the major risk factor for neurodegenerative diseases including Parkinson’s disease (PD). Telomere shortening is associated with cellular senescence. In this regard, pharmacological or genetic inhibition of telomerase activity has been used to model cellular aging. Here, we employ...

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Detalles Bibliográficos
Autores principales: Kim, Hyojung, Ham, Sangwoo, Jo, Minkyung, Lee, Gum Hwa, Lee, Yun-Song, Shin, Joo-Ho, Lee, Yunjong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666775/
https://www.ncbi.nlm.nih.gov/pubmed/28972555
http://dx.doi.org/10.3390/ijms18102093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666775/
https://www.ncbi.nlm.nih.gov/pubmed/28972555
http://dx.doi.org/10.3390/ijms18102093

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