Combined Virtual and Experimental Screening for CK1 Inhibitors Identifies a Modulator of p53 and Reveals Important Aspects of in Silico Screening Performance

A compound collection of pronounced structural diversity was comprehensively screened for inhibitors of the DNA damage-related kinase CK1. The collection was evaluated in vitro. A potent and selective CK1 inhibitor was discovered and its capacity to modulate the endogenous levels of the CK1-regulate...

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Detalles Bibliográficos
Autores principales: Myrianthopoulos, Vassilios, Lozach, Olivier, Zareifi, Danae, Alexopoulos, Leonidas, Meijer, Laurent, Gorgoulis, Vassilis G., Mikros, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666784/
https://www.ncbi.nlm.nih.gov/pubmed/28984824
http://dx.doi.org/10.3390/ijms18102102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666784/
https://www.ncbi.nlm.nih.gov/pubmed/28984824
http://dx.doi.org/10.3390/ijms18102102

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