Cargando…

Impact of Natural Compounds on DNA Methylation Levels of the Tumor Suppressor Gene RASSF1A in Cancer

Epigenetic inactivation of tumor suppressor genes (TSG) is a fundamental event in the pathogenesis of human cancer. This silencing is accomplished by aberrant chromatin modifications including DNA hypermethylation of the gene promoter. One of the most frequently hypermethylated TSG in human cancer i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dammann, Reinhard H., Richter, Antje M., Jiménez, Adriana P., Woods, Michelle, Küster, Miriam, Witharana, Chamindri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666841/ https://www.ncbi.nlm.nih.gov/pubmed/29039788 http://dx.doi.org/10.3390/ijms18102160

Ejemplares similares

Aberrant Promoter Methylation of the Tumour Suppressor RASSF10 and Its Growth Inhibitory Function in Breast Cancer
por: Richter, Antje M., et al.
Publicado: (2016)

RASSF10 Is a TGFβ-Target That Regulates ASPP2 and E-Cadherin Expression and Acts as Tumor Suppressor That Is Epigenetically Downregulated in Advanced Cancer
por: Richter, Antje M., et al.
Publicado: (2019)

The SARAH Domain of RASSF1A and Its Tumor Suppressor Function
por: Dittfeld, Claudia, et al.
Publicado: (2012)

RASSF10 is frequently epigenetically inactivated in kidney cancer and its knockout promotes neoplasia in cancer prone mice
por: Richter, Antje M., et al.
Publicado: (2020)

The tumor suppressor RASSF1A induces the YAP1 target gene ANKRD1 that is epigenetically inactivated in human cancers and inhibits tumor growth
por: Jiménez, Adriana P., et al.
Publicado: (2017)

Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences
por: Schagdarsurengin, Undraga, et al.
Publicado: (2010)

RASSF6; the Putative Tumor Suppressor of the RASSF Family
por: Iwasa, Hiroaki, et al.
Publicado: (2015)

The tumor suppressor RASSF10 is upregulated upon contact inhibition and frequently epigenetically silenced in cancer
por: Richter, A M, et al.
Publicado: (2012)

The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma
por: Djos, Anna, et al.
Publicado: (2012)

Aberrant Promoter Hypermethylation of RASSF Family Members in Merkel Cell Carcinoma
por: Richter, Antje M., et al.
Publicado: (2013)

The Effectiveness of the Nimali Variety of Sri Lankan Punica granatum L. Fruit Extracts on Rhabdomyosarcoma (RD) Cells Concerning the Apoptotic Signaling Pathway
por: Bandara, Udeshika Yapa, et al.
Publicado: (2022)

The impact of the RASSF1C and PIWIL1 on DNA methylation: the identification of GMIP as a tumor suppressor
por: Amaar, Yousef G., et al.
Publicado: (2020)

Tumor Suppressor RASSF1A Promoter: p53 Binding and Methylation
por: Tian, Yihao, et al.
Publicado: (2011)

Awareness of female malignancies among women and their partners in Southern Sri Lanka and implications for screening: a cross sectional study
por: Witharana, Chamindri, et al.
Publicado: (2015)

Reactivation of the Tumour Suppressor RASSF1A in Breast Cancer by Simultaneous Targeting of DNA and E2F1 Methylation
por: Montenegro, María F., et al.
Publicado: (2012)

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias
por: Hesson, Luke B, et al.
Publicado: (2009)

Regulation of RASSF by non-coding RNAs in different cancers: RASSFs as masterminds of their own destiny as tumor suppressors and oncogenes
por: Farooqi, Ammad Ahmad, et al.
Publicado: (2022)

Epigenetic Inactivation of the Tumor Suppressor IRX1 Occurs Frequently in Lung Adenocarcinoma and Its Silencing Is Associated with Impaired Prognosis
por: Küster, Miriam M., et al.
Publicado: (2020)

ZAR1 is a novel epigenetically inactivated tumour suppressor in lung cancer
por: Richter, Antje M., et al.
Publicado: (2017)

The Role of RASSF1A Methylation in Cancer
por: Hesson, Luke B., et al.
Publicado: (2007)

Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation
por: Li, Wenjiao, et al.
Publicado: (2018)

RASSF1A Tumour Suppressor: Target the Network for Effective Cancer Therapy
por: García-Gutiérrez, Lucía, et al.
Publicado: (2020)

Combined RASSF1A and RASSF2A Promoter Methylation Analysis as Diagnostic Biomarker for Bladder Cancer
por: Meng, Wei, et al.
Publicado: (2012)

RASSF1A Site-Specific Methylation Hotspots in Cancer and Correlation with RASSF1C and MOAP-1
por: Volodko, Natalia, et al.
Publicado: (2016)

Aberrant DNA Methylation of rDNA and PRIMA1 in Borderline Personality Disorder
por: Teschler, Stefanie, et al.
Publicado: (2016)

Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1C in pancreatic endocrine tumors
por: Malpeli, Giorgio, et al.
Publicado: (2011)

High Mutability of the Tumor Suppressor Genes RASSF1 and RBSP3 (CTDSPL) in Cancer
por: Kashuba, Vladimir I., et al.
Publicado: (2009)

Frequent Promoter Hypermethylation of the APC and RASSF1A Tumour Suppressors in Parathyroid Tumours
por: Juhlin, C. Christofer, et al.
Publicado: (2010)

RASSF10 is an epigenetically inactivated tumor suppressor and independent prognostic factor in hepatocellular carcinoma
por: Wang, Fei, et al.
Publicado: (2015)

The Diagnostic Potential of SHOX2 and RASSF1A DNA Methylation in Early Lung Adenocarcinoma
por: Gao, Hong, et al.
Publicado: (2022)

Promoter Methylation Status of Ras-Association Domain Family Members in Pheochromocytoma
por: Richter, Antje M., et al.
Publicado: (2015)

Clinical utility of RASSF1A methylation in human malignancies
por: Grawenda, A M, et al.
Publicado: (2015)

Methylation Dynamics of RASSF1A and Its Impact on Cancer
por: Malpeli, Giorgio, et al.
Publicado: (2019)

The Tumor Suppressor Gene, RASSF1A, Is Essential for Protection against Inflammation -Induced Injury
por: Gordon, Marilyn, et al.
Publicado: (2013)

MUC1-C REPRESSES THE RASSF1A TUMOR SUPPRESSOR IN HUMAN CARCINOMA CELLS
por: Rajabi, Hasan, et al.
Publicado: (2019)

RASSF Signalling and DNA Damage: Monitoring the Integrity of the Genome?
por: Scrace, Simon F., et al.
Publicado: (2012)

The RASSF1 Gene and the Opposing Effects of the RASSF1A and RASSF1C Isoforms on Cell Proliferation and Apoptosis
por: Reeves, Mark E., et al.
Publicado: (2013)

RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker
por: Jin, Yongshuai, et al.
Publicado: (2015)

The dual specificity phosphatase 2 gene is hypermethylated in human cancer and regulated by epigenetic mechanisms
por: Haag, Tanja, et al.
Publicado: (2016)

Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome
por: Xu, Jia, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_qtt647pp12uem3gkand7fc9co4