Nrf2-Inducers Counteract Neurodegeneration in Frataxin-Silenced Motor Neurons: Disclosing New Therapeutic Targets for Friedreich’s Ataxia

Oxidative stress is actively involved in Friedreich’s Ataxia (FA), thus pharmacological targeting of the antioxidant machinery may have therapeutic value. Here, we analyzed the relevance of the antioxidant phase II response mediated by the transcription factor Nrf2 on frataxin-deficient cultured mot...

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Detalles Bibliográficos
Autores principales: Petrillo, Sara, Piermarini, Emanuela, Pastore, Anna, Vasco, Gessica, Schirinzi, Tommaso, Carrozzo, Rosalba, Bertini, Enrico, Piemonte, Fiorella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666854/
https://www.ncbi.nlm.nih.gov/pubmed/29057804
http://dx.doi.org/10.3390/ijms18102173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666854/
https://www.ncbi.nlm.nih.gov/pubmed/29057804
http://dx.doi.org/10.3390/ijms18102173

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