The MEK Inhibitors Trametinib and Cobimetinib Induce a Type I Interferon Response in Human Keratinocytes

Mitogen-activated protein kinase kinases (MEK) 1 and 2 have crucial roles in tumorigenesis, cell proliferation, and protection from apoptosis, and their inhibition is therefore an attractive therapeutic strategy in cancer. Orally available and highly selective MEK inhibitors have been developed and...

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Detalles Bibliográficos
Autores principales: Lulli, Daniela, Carbone, Maria Luigia, Pastore, Saveria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666906/
https://www.ncbi.nlm.nih.gov/pubmed/29064427
http://dx.doi.org/10.3390/ijms18102227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666906/
https://www.ncbi.nlm.nih.gov/pubmed/29064427
http://dx.doi.org/10.3390/ijms18102227

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