Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors

Src-family kinases (SFKs) play important roles in human biology and are key drug targets as well. However, achieving selective inhibition of individual Src-family kinases is challenging due to the high similarity within the protein family. We describe rhodium(ii) conjugates that deliver both potent...

Descripción completa

Detalles Bibliográficos
Autores principales: Vohidov, Farrukh, Knudsen, Sarah E., Leonard, Paul G., Ohata, Jun, Wheadon, Michael J., Popp, Brian V., Ladbury, John E., Ball, Zachary T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667506/
https://www.ncbi.nlm.nih.gov/pubmed/29142714
http://dx.doi.org/10.1039/c5sc01602a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667506/
https://www.ncbi.nlm.nih.gov/pubmed/29142714
http://dx.doi.org/10.1039/c5sc01602a

Ejemplares similares