Phospholipase A2 is involved in galactosylsphingosine-induced astrocyte toxicity, neuronal damage and demyelination

Krabbe disease is a fatal rare inherited lipid storage disorder affecting 1:100,000 births. This illness is caused by mutations in the galc gene encoding for the enzyme galactosylceramidase (GALC). Dysfunction of GALC has been linked to the toxic build-up of the galactolipid, galactosylsphingosine (...

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Detalles Bibliográficos
Autores principales: Misslin, Cedric, Velasco-Estevez, Maria, Albert, Marie, O’Sullivan, Sinead A., Dev, Kumlesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667767/
https://www.ncbi.nlm.nih.gov/pubmed/29095858
http://dx.doi.org/10.1371/journal.pone.0187217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667767/
https://www.ncbi.nlm.nih.gov/pubmed/29095858
http://dx.doi.org/10.1371/journal.pone.0187217

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