Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis

The segmental pattern of the vertebrate body is established via the periodic formation of somites from the presomitic mesoderm (PSM). This periodical process is controlled by the cyclic and synchronized activation of Notch signaling in the PSM. Protein O-fucosyltransferase1 (Pofut1), which transfers...

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Detalles Bibliográficos
Autores principales: Ajima, Rieko, Suzuki, Emiko, Saga, Yumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667770/
https://www.ncbi.nlm.nih.gov/pubmed/29095923
http://dx.doi.org/10.1371/journal.pone.0187248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667770/
https://www.ncbi.nlm.nih.gov/pubmed/29095923
http://dx.doi.org/10.1371/journal.pone.0187248

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