S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis

MicroRNA-34a (miR-34a) is down-regulated in colorectal cancers (CRC) and required for interleukin-6 (IL-6)-induced CRC metastasis. Mice lacking miR-34a developed more invasive cancer in a colitis-associated cancer model. In the same model, S-adenosylmethionine (SAMe) and methylthioadenosine (MTA) in...

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Detalles Bibliográficos
Autores principales: Tomasi, Maria Lauda, Cossu, Carla, Spissu, Ylenia, Floris, Andrea, Ryoo, Minjung, Iglesias-Ara, Ainhoa, Wang, Qiang, Pandol, Stephen J., Bhowmick, Neil A., Seki, Ekihiro, Posadas, Edwin M., Lu, Shelly C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668003/
https://www.ncbi.nlm.nih.gov/pubmed/29108270
http://dx.doi.org/10.18632/oncotarget.20234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668003/
https://www.ncbi.nlm.nih.gov/pubmed/29108270
http://dx.doi.org/10.18632/oncotarget.20234

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