PARK14 PLA2G6 mutants are defective in preventing rotenone-induced mitochondrial dysfunction, ROS generation and activation of mitochondrial apoptotic pathway

Mutations in the gene encoding Ca(2+)-independent phospholipase A(2) group 6 (PLA2G6) cause the recessive familial type 14 of Parkinson’s disease (PARK14). Mitochondrial dysfunction is involved in the pathogenesis of Parkinson’s disease (PD). PLA2G6 is believed to be required for maintaining mitocho...

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Detalles Bibliográficos
Autores principales: Chiu, Ching-Chi, Yeh, Tu-Hsueh, Lu, Chin-Song, Huang, Yin-Cheng, Cheng, Yi-Chuan, Huang, Ying-Zu, Weng, Yi-Hsin, Liu, Yu-Chuan, Lai, Szu-Chia, Chen, Ying-Ling, Chen, Yu-Jie, Chen, Chao-Lang, Chen, Hsin-Yi, Lin, Yan-Wei, Wang, Hung-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668019/
https://www.ncbi.nlm.nih.gov/pubmed/29108286
http://dx.doi.org/10.18632/oncotarget.20893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668019/
https://www.ncbi.nlm.nih.gov/pubmed/29108286
http://dx.doi.org/10.18632/oncotarget.20893

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