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Translation efficiency is a determinant of the magnitude of miRNA-mediated repression

MicroRNAs are well known regulators of mRNA stability and translation. However, the magnitude of both translational repression and mRNA decay induced by miRNA binding varies greatly between miRNA targets. This can be the result of cis and trans factors that affect miRNA binding or action. We set out...

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Detalles Bibliográficos
Autores principales: Cottrell, Kyle A., Szczesny, Pawel, Djuranovic, Sergej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668238/
https://www.ncbi.nlm.nih.gov/pubmed/29097662
http://dx.doi.org/10.1038/s41598-017-13851-w