Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1α-dependent decay

Long chain fatty acids (LCFAs) exert pro-inflammatory effects in vivo. However, little is known regarding the effect of LCFAs on invariant (i) NKT cell functions. Here, we report an inhibitory effect of saturated LCFAs on transcription factors in iNKT cells. Among the saturated LCFAs, palmitic acid...

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Detalles Bibliográficos
Autores principales: Ko, Jae Sung, Koh, Jae Moon, So, Jae-Seon, Jeon, Yoon Kyung, Kim, Hye Young, Chung, Doo Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668299/
https://www.ncbi.nlm.nih.gov/pubmed/29097726
http://dx.doi.org/10.1038/s41598-017-14780-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668299/
https://www.ncbi.nlm.nih.gov/pubmed/29097726
http://dx.doi.org/10.1038/s41598-017-14780-4

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