Cargando…

IPET study: an FLT-PET window study to assess the activity of the steroid sulfatase inhibitor irosustat in early breast cancer

BACKGROUND: Steroid sulfatase (STS) is involved in oestrogen biosynthesis and irosustat is a first generation, irreversible steroid sulfatase inhibitor. A pre-surgical window-of-opportunity study with irosustat was undertaken in estrogen receptor-positive (ER+) breast cancer to assess the effect of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Palmieri, Carlo, Szydlo, Richard, Miller, Marie, Barker, Laura, Patel, Neva H., Sasano, Hironobu, Barwick, Tara, Tam, Henry, Hadjiminas, Dimitri, Lee, Jasmin, Shaaban, Abeer, Nicholas, Hanna, Coombes, R. Charles, Kenny, Laura M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2017
Materias:	Clinical Trial
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668341/ https://www.ncbi.nlm.nih.gov/pubmed/28795252 http://dx.doi.org/10.1007/s10549-017-4427-x

Ejemplares similares

IRIS study: a phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patients
por: Palmieri, Carlo, et al.
Publicado: (2017)

Structure–Activity Relationship for the First-in-Class Clinical Steroid Sulfatase Inhibitor Irosustat (STX64, BN83495)
por: Woo, L W Lawrence, et al.
Publicado: (2011)

Novel Anti-Acanthamoebic Activities of Irosustat and STX140 and Their Nanoformulations
por: Siddiqui, Ruqaiyyah, et al.
Publicado: (2023)

In breast cancer subtypes steroid sulfatase (STS) is associated with less aggressive tumour characteristics
por: McNamara, Keely M, et al.
Publicado: (2018)

Intelligent Physical Exercise Training (IPET) in the offshore wind industry: a feasibility study with an adjusted conceptual model
por: Oestergaard, Anne Skov, et al.
Publicado: (2022)

Can we see what is invisible? The role of MRI in the evaluation and management of patients with pathological nipple discharge
por: Zacharioudakis, Konstantinos, et al.
Publicado: (2019)

IPET and FETR: Experimental Approach for Studying Molecular Structure Dynamics by Cryo-Electron Tomography of a Single-Molecule Structure
por: Zhang, Lei, et al.
Publicado: (2012)

Aromatase expression and outcomes in the P024 neoadjuvant endocrine therapy trial
por: Ellis, Matthew J., et al.
Publicado: (2008)

Evaluation of applying IHC4 as a prognostic model in the translational study of Intergroup Exemestane Study (IES): PathIES
por: Cheang, M. C. U., et al.
Publicado: (2017)

Sulfatase 1 and sulfatase 2 as novel regulators of macrophage antigen presentation and phagocytosis
por: Kim, Hyun-Je, et al.
Publicado: (2021)

A randomized, double-blind, controlled study of exemestane versus anastrozole for the first-line treatment of postmenopausal Japanese women with hormone-receptor-positive advanced breast cancer
por: Iwata, Hiroji, et al.
Publicado: (2013)

Phase III study of long-term prognosis of estrogen receptor-positive early breast cancer treated with neoadjuvant endocrine therapy with/without adjuvant chemotherapy
por: Iwata, Hiroji, et al.
Publicado: (2023)

Midostaurin plus intensive chemotherapy for younger and older patients with AML and FLT3 internal tandem duplications
por: Döhner, Hartmut, et al.
Publicado: (2022)

Molecular profile of FLT3-mutated relapsed/refractory patients with AML in the phase 3 ADMIRAL study of gilteritinib
por: Smith, Catherine C., et al.
Publicado: (2022)

Prognostic impact of NPM1 and FLT3 mutations in patients with AML in first remission treated with oral azacitidine
por: Döhner, Hartmut, et al.
Publicado: (2022)

Quantification of the enzyme activities of iduronate-2-sulfatase, N-acetylgalactosamine-6-sulfatase and N-acetylgalactosamine-4-sulfatase using liquid chromatography-tandem mass spectrometry
por: Mashima, Ryuichi, et al.
Publicado: (2017)

Dissecting the predictive value of MAPK/AKT/estrogen-receptor phosphorylation axis in primary breast cancer to treatment response for tamoxifen over exemestane: a Translational Report of the Intergroup Exemestane Study (IES)—PathIES
por: Szijgyarto, Zsolt, et al.
Publicado: (2019)

Phylogeny of Algal Sequences Encoding Carbohydrate Sulfotransferases, Formylglycine-Dependent Sulfatases, and Putative Sulfatase Modifying Factors
por: Ho, Chai-Ling
Publicado: (2015)

Follow-up of patients with R/R FLT3-mutation–positive AML treated with gilteritinib in the phase 3 ADMIRAL trial
por: Perl, Alexander E., et al.
Publicado: (2022)

Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish
por: Schenk, Heiko, et al.
Publicado: (2019)

Phase 3 trial of gilteritinib plus azacitidine vs azacitidine for newly diagnosed FLT3(mut+) AML ineligible for intensive chemotherapy
por: Wang, Eunice S., et al.
Publicado: (2022)

Multiple sulfatase deficiency with neonatal manifestation
por: Garavelli, Livia, et al.
Publicado: (2014)

Comparison of two targeted ultra-deep sequencing technologies for analysis of plasma circulating tumour DNA in endocrine-therapy-resistant breast cancer patients
por: Nteliopoulos, Georgios, et al.
Publicado: (2021)

A conceptual model for worksite intelligent physical exercise training - IPET - intervention for decreasing life style health risk indicators among employees: a randomized controlled trial
por: Sjøgaard, Gisela, et al.
Publicado: (2014)

Validation of the 21-gene test as a predictor of clinical response to neoadjuvant hormonal therapy for ER+, HER2-negative breast cancer: the TransNEOS study
por: Iwata, Hiroji, et al.
Publicado: (2018)

Impact of FLT3 Mutation on Outcomes after Venetoclax and Azacitidine for Patients with Treatment-Naïve Acute Myeloid Leukemia
por: Konopleva, Marina, et al.
Publicado: (2022)

Late infantile form of multiple sulfatase deficiency
por: Mohammadian Khonsari, Nami, et al.
Publicado: (2020)

Sulfatase-cleavable linkers for antibody-drug conjugates
por: Bargh, Jonathan D., et al.
Publicado: (2020)

Sulfatases: Critical Enzymes for Algal Polysaccharide Processing
por: Hettle, Andrew G., et al.
Publicado: (2022)

Mammalian Sulfatases: Biochemistry, Disease Manifestation, and Therapy
por: Mashima, Ryuichi, et al.
Publicado: (2022)

Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester
por: van Loo, Bert, et al.
Publicado: (2018)

Changes in Glycogen and Glycosaminoglycan Levels in Hepatocytes of Iduronate-2-Sulfatase Knockout Mice before and after Recombinant Iduronate-2-Sulfatase Supplementation
por: Lee, Jee Hyun, et al.
Publicado: (2011)

The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases
por: Rižner, Tea Lanišnik
Publicado: (2016)

Sulfatase‐mediated manipulation of the astrocyte‐Schwann cell interface
por: O'Neill, Paul, et al.
Publicado: (2016)

Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases
por: Reuillon, Tristan, et al.
Publicado: (2016)

Practical Windows forensics: leverage the power of digital forensics for Windows systems
por: Shaaban, Ayman, et al.
Publicado: (2016)

Multiple sulfatase deficiency: A case series of four children
por: Incecik, Faruk, et al.
Publicado: (2013)

Microbial alkyl- and aryl-sulfatases: mechanism, occurrence, screening and stereoselectivities
por: Toesch, Michael, et al.
Publicado: (2013)

Bioinformatic Analysis of the Human Recombinant Iduronate 2-Sulfate Sulfatase
por: Morales-Álvarez, Edwin D., et al.
Publicado: (2016)

Steroid Sulfatase Deficiency and Androgen Activation Before and After Puberty
por: Idkowiak, Jan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_4ksa9el4mnjb7a8mnuas56qblg