20(S)-Protopanaxadiol enhances angiogenesis via HIF-1α-mediated VEGF secretion by activating p70S6 kinase and benefits wound healing in genetically diabetic mice

Impaired angiogenesis is one of the crucial factors that impede the wound healing process in diabetic foot ulcers (DFUs). In this study, we found that 20(S)-protopanaxadiol (PPD), an aglycone of ginsenosides in Panax notoginseng, stimulated angiogenesis and benefited wound healing in genetically dia...

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Detalles Bibliográficos
Autores principales: Zhang, Er-Yun, Gao, Bo, Shi, Hai-Lian, Huang, Ling-Fang, Yang, Li, Wu, Xiao-Jun, Wang, Zheng-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668468/
https://www.ncbi.nlm.nih.gov/pubmed/29075038
http://dx.doi.org/10.1038/emm.2017.151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668468/
https://www.ncbi.nlm.nih.gov/pubmed/29075038
http://dx.doi.org/10.1038/emm.2017.151

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