Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation

The AML1/Runx1 transcription factor and its heterodimerization partner CBFβ are essential regulators of myeloid differentiation. The chromosomal translocation t(8;21), fusing the DNA binding domain of AML1 to the corepressor eight-twenty-one (ETO), is frequently associated with acute myeloid leukemi...

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Detalles Bibliográficos
Autores principales: Thiel, V N, Giaimo, B D, Schwarz, P, Soller, K, Vas, V, Bartkuhn, M, Blätte, T J, Döhner, K, Bullinger, L, Borggrefe, T, Geiger, H, Oswald, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668496/
https://www.ncbi.nlm.nih.gov/pubmed/28360416
http://dx.doi.org/10.1038/leu.2017.105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668496/
https://www.ncbi.nlm.nih.gov/pubmed/28360416
http://dx.doi.org/10.1038/leu.2017.105

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