Liposomal delivery of a phosphodiesterase 3 inhibitor rescues low oxygen-induced ATP release from erythrocytes of humans with type 2 diabetes

ATP release from erythrocytes in response to low oxygen tension requires an increase in cAMP, the level of which is regulated by phosphodiesterase 3 (PDE3). Such release is defective in erythrocytes of humans with type 2 diabetes (DM2). This study tested a hypothesis that direct delivery of the clin...

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Detalles Bibliográficos
Autores principales: Dergunov, Sergey A., Bowles, Elizabeth A., Gordon, Weston, Green, Michael, Bierman, August, Ellsworth, Mary L., Pinkhassik, Eugene, Sprague, Randy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668668/
https://www.ncbi.nlm.nih.gov/pubmed/29124155
http://dx.doi.org/10.1016/j.bbrep.2015.05.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668668/
https://www.ncbi.nlm.nih.gov/pubmed/29124155
http://dx.doi.org/10.1016/j.bbrep.2015.05.011

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