The histone deacetylase inhibitor cambinol prevents acidic pH(e)-induced anterograde lysosome trafficking independently of sirtuin activity

Common features of the solid tumor microenvironment, such as acidic extracellular pH and growth factors, are known to induce the redistribution of lysosomes from a perinuclear region to a position near the plasma membrane. Lysosome/plasma membrane juxtaposition facilitates invasion by allowing for t...

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Detalles Bibliográficos
Autores principales: Dykes, Samantha S., Friday, Ellen, Pruitt, Kevin, Cardelli, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668693/
https://www.ncbi.nlm.nih.gov/pubmed/29124170
http://dx.doi.org/10.1016/j.bbrep.2015.07.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668693/
https://www.ncbi.nlm.nih.gov/pubmed/29124170
http://dx.doi.org/10.1016/j.bbrep.2015.07.015

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