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The histone deacetylase inhibitor cambinol prevents acidic pH(e)-induced anterograde lysosome trafficking independently of sirtuin activity
Common features of the solid tumor microenvironment, such as acidic extracellular pH and growth factors, are known to induce the redistribution of lysosomes from a perinuclear region to a position near the plasma membrane. Lysosome/plasma membrane juxtaposition facilitates invasion by allowing for t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668693/ https://www.ncbi.nlm.nih.gov/pubmed/29124170 http://dx.doi.org/10.1016/j.bbrep.2015.07.015 |