Transthyretin chemical chaperoning by flavonoids: Structure–activity insights towards the design of potent amyloidosis inhibitors

BACKGROUND: Many polyphenols have been proposed as broad-spectrum inhibitors of amyloid formation. To investigate structure–activity relationships relevant for the interaction of flavonoids with transthyretin (TTR), the protein associated with familial amyloid polyneuropathy (FAP), we compared the e...

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Detalles Bibliográficos
Autores principales: Ferreira, Nelson, Pereira-Henriques, Alda, Almeida, Maria Rosário
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668852/
https://www.ncbi.nlm.nih.gov/pubmed/29124175
http://dx.doi.org/10.1016/j.bbrep.2015.07.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668852/
https://www.ncbi.nlm.nih.gov/pubmed/29124175
http://dx.doi.org/10.1016/j.bbrep.2015.07.019

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