Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes

Genome-wide association studies (GWAS) have identified multiple, shared allelic associations with many autoimmune diseases. However, the pathogenic contributions of variants residing in risk loci remain unresolved. The location of the majority of shared disease-associated variants in noncoding regio...

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Detalles Bibliográficos
Autores principales: Newman, Jeremy R.B., Conesa, Ana, Mika, Matthew, New, Felicia N., Onengut-Gumuscu, Suna, Atkinson, Mark A., Rich, Stephen S., McIntyre, Lauren M., Concannon, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668939/
https://www.ncbi.nlm.nih.gov/pubmed/29025893
http://dx.doi.org/10.1101/gr.217984.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668939/
https://www.ncbi.nlm.nih.gov/pubmed/29025893
http://dx.doi.org/10.1101/gr.217984.116

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