Nascent RNA sequencing reveals a dynamic global transcriptional response at genes and enhancers to the natural medicinal compound celastrol

Most studies of responses to transcriptional stimuli measure changes in cellular mRNA concentrations. By sequencing nascent RNA instead, it is possible to detect changes in transcription in minutes rather than hours and thereby distinguish primary from secondary responses to regulatory signals. Here...

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Detalles Bibliográficos
Autores principales: Dukler, Noah, Booth, Gregory T., Huang, Yi-Fei, Tippens, Nathaniel, Waters, Colin T., Danko, Charles G., Lis, John T., Siepel, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668940/
https://www.ncbi.nlm.nih.gov/pubmed/29025894
http://dx.doi.org/10.1101/gr.222935.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668940/
https://www.ncbi.nlm.nih.gov/pubmed/29025894
http://dx.doi.org/10.1101/gr.222935.117

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