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Accounting for GC-content bias reduces systematic errors and batch effects in ChIP-seq data
The main application of ChIP-seq technology is the detection of genomic regions that bind to a protein of interest. A large part of functional genomics’ public catalogs is based on ChIP-seq data. These catalogs rely on peak calling algorithms that infer protein-binding sites by detecting genomic reg...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668949/ https://www.ncbi.nlm.nih.gov/pubmed/29025895 http://dx.doi.org/10.1101/gr.220673.117 |