Donor variability may mask dimethyl fumarate’s effects on nuclear factor E2-related factor 2 in human peripheral blood mononuclear cells

OBJECTIVE: Dimethyl fumarate (DMF) is an anti-inflammatory and antioxidant drug used to treat multiple sclerosis, but its mechanism(s) of action are not fully understood. In central nervous system (CNS) cells, DMF activates nuclear factor E2-related factor 2 (Nrf2), perhaps ameliorating oxidative st...

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Detalles Bibliográficos
Autores principales: Fiedler, Sarah E., Kerns, Amelia R., Tsang, Catherine, Love, Haley N., Salinthone, Sonemany
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669026/
https://www.ncbi.nlm.nih.gov/pubmed/29096692
http://dx.doi.org/10.1186/s13104-017-2862-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669026/
https://www.ncbi.nlm.nih.gov/pubmed/29096692
http://dx.doi.org/10.1186/s13104-017-2862-8

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