Colchicine Depolymerizes Microtubules, Increases Junctophilin‐2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension

BACKGROUND: Pulmonary arterial hypertension (PAH) is a lethal disease characterized by obstructive pulmonary vascular remodeling and right ventricular (RV) dysfunction. Although RV function predicts outcomes in PAH, mechanisms of RV dysfunction are poorly understood, and RV‐targeted therapies are la...

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Detalles Bibliográficos
Autores principales: Prins, Kurt W., Tian, Lian, Wu, Danchen, Thenappan, Thenappan, Metzger, Joseph M., Archer, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669202/
https://www.ncbi.nlm.nih.gov/pubmed/28566298
http://dx.doi.org/10.1161/JAHA.117.006195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669202/
https://www.ncbi.nlm.nih.gov/pubmed/28566298
http://dx.doi.org/10.1161/JAHA.117.006195

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